After establishment of a process for assessment of technical developability already during the antibody selection process he is currently responsible for antibody phage display selections done in Basel.
He did his Ph. At Pfizer as a Principal Scientist he engineered phage display libraries, developed repertoire analysis algorithms, and published multiple methods for deep repertoire sequencing and antibody library optimization.
He publishes research in multiple areas of human immunology including oncology, vaccination, allergy and autoimmunity in the Computational and Systems Immunology PhD program at Stanford University, and is a Scientific Advisory Board member for the University of San Francisco Biotechnology PSM program.
At Distributed Bio, he leads the computational and physical biologics engineering initiatives. He developed the science and algorithms behind AbGenesis - the world-leading licensable platform for advanced repertoire analysis, advanced library engineering, and in-vivo immune repertoire analysis now used ubiquitously in biologics research. Dr Carol Harley obtained her Ph. She specializes in the Thesis Binders University Of London of innovative molecular imaging approaches with nanochemistry techniques to produce next-generation cell labelling go here for the in vivo assessment of cell trafficking.
Her research has therefore largely focuses on supporting the advance of T cell and stem cells therapies in animals and man. She previously obtained her Ph. His work spans from basic structural and functional studies of different antibody isotypes to construction of large antibody phage libraries and target selection for clinical development. The focus of this work has been to use phage display for engineering T cell receptor structures that allow for Thesis Binders University Of London molecular characterization of T cell responses in myeloma and Celiac disease.
John McCafferty was one of the founders of Cambridge Antibody Technology now Medimmune and was principle inventor of antibody phage display in In John set up a group at the Sanger Institute developing and utilizing methods for protein generation and recombinant antibody isolation in high throughput for research applications.
More recently John formed a laboratory at the Biochemistry Department at University of Cambridge utilizing phage display technology to develop functionally blocking antibodies with potential in cancer and stem cell biology. In this role he worked on the isolation and optimisation of antibodies which are now undergoing clinical trials, including the recently-approved BenLysta.
For several years Ralph then headed the Lead Optimisation team, which used phage and ribosome display to optimise the potency of over 50 antibodies, many of which are currently in preclinical and clinical studies, either in house or with collaborators.
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Ralph is currently a Fellow in the Antibody Discovery and Protein Engineering group at MedImmune and is running a wide range of projects, covering novel target discovery, protein engineering and novel http://cyprus4u.info/repository/words-to-use-in-a-how-to-essay.php platforms.
Molkenthin is the Chief Scientist of AbCheck s. AbCheck uses a unique combination of Phage and Yeast Display for Antibody Discovery and has several ongoing collaboration projects with biopharmaceutical companies. Vera was part of the founding team of AbCheck in He got his PhD with distinction, in the Dept.
His work focuses on the study of protein interaction using computational and molecular approaches. A major focus of Dr. Biolojic Design, founded indeveloped a combined computational-molecular platform for the design of antibodies against pre-selected epitopes on difficult targets.
Smith joined Vaccinex at its inception in and was a key developer of its core cDNA library and antibody discovery technologies. In his current position, Dr.
Smith has a Ph. In Wyeth he went on to lead an expanded group that also included molecular modeling and protein biochemistry that provided protein reagents to groups throughout the company and collaborated with teams on structure based small molecule design. Most recently he headed the Global Biotherapeutic Technologies group at Pfizer that is responsible for discovering and optimizing biotherapeutics in collaboration with all the Research Units. The group has a diverse portfolio consisting of antibodies, antibody drug conjugates and endogenous proteins.
One of the groups strengths were the use of innovative structure based engineering techniques that were successfully applied to improve both the potency and properties of therapeutic leads. These methods have contributed to a pipeline of differentiated biotherapeutics that are currently in development. Jens Thostrup Bukrinski, Ph. His experience ranges from small synthetic peptides to large recombinant proteins such as mAbs and coagulation factors for the treatment of diabetes, obesity, hemophilia and autoimmune diseases.
Jens holds a master in Dairy Science and a Ph. His teams utilises the core technologies of phage and ribosome display, as well as in vivo platforms to discover and engineer mAbs and, together with Protein Sciences and High Throughput Screening teams, support four disease areas.
Tris is check this out University of Leeds graduate from the Thesis Binders University Of London Department. He earned a B. Andrews before undertaking a Ph.
D and post-doctoral work in protein folding at the University of Cambridge. She subsequently moved to Covagen AG, a biotechnology company based in Zurich, Switzerland, and worked on the optimisation of their lead molecule which is currently entering clinical trials for the treatment of inflammatory diseases.
The lead programme was later licenced to BMS. Sarah has several peer-reviewed papers and is named as an inventor on a number of patents and patent applications. Bohne studied Biology at the University of Konstanz and graduated on the blue-light regulated biosynthesis of carotenoids in single celled green algae.
For his PhD in Cologne, Germany, he switched to the field of virology and generated chimeric antigen receptors redirecting T cells towards HBV-infected hepatocytes for the treatment read more chronic hepatitis B.
As a post doc in Barcelona, he was working on transplantation tolerance in chronically HCV-infected liver recipients which seem to regulate organ acceptance through a virus mediated hypo responsiveness of immune cells. At go here moment, Dr.
Bohne is a group leader at the Institute of Virology in Munich and is developing novel immunotherapeutic antibodies for therapy of chronic hepatitis B and HBV-associated tumors. Mark received his training from: His work experience has spanned from being an Organic Chemist at Microgenics developing chemical conjugation of enzymes; Chemistry Thesis Binders University Of London at Seton Hall University getting grants on prokaryotic membrane protein biochemistry; Research Investigator at Abbott Labs on Mammalian Membrane Protein Drug Discovery; and now currently as Associate Director at Janssen Research and Development leading the Discovery and pre-clinical development of multi-specific Biotherapeutics.
Marshall has been developing applications of recombinant antibodies for the last fifteen years at Randox Laboratories. Kathryn Wood developing viral-based Thesis Binders University Of London therapy strategies to induce immunological tolerance in transplantation.
He now leads a team within the company focusing on providing innovative solutions for clients that radically improve our understanding of both desired and unwanted immune responses. Tariq Ghayur received his Ph.
Fromhe led two therapeutic antibody discovery project teams and delivered 2 drug development candidates. Currently four DVD-Ig molecules are in clinical development.
Jijie Gu received his Ph. He joined Abbott Laboratories in Jijie Gu has more than 13 years of industry experience in therapeutic antibody and novel biologics engineering, discovery and early development in several therapeutic areas including metabolic diseases, neuroscience, immunology, oncology and ophthalmology.
As a project leader or co-leader, he has initiated and delivered several drug development candidates including the ones currently in clinical trials. He is a co-author for many peer reviewed articles and a co-inventor for several issued and filed US and international patents.
He is also on the editorial Atreus Essay Of Treasury of mAbs journal. Igawa joined Chugai Pharmaceutical in He was established pH-dependent binding antibody and bispecific antibody technologies, and served as project leader of antibody therapeutic projects now in late-stage clinical study. Currently, he is group manager of Discovery Research Department, antibody engineering and optimization, library display, protein science and early CMC development.
Trained in infectious diseases, Dr. Lowy was at Medarex Inc. At Medarex, he led numerous efforts in infectious diseases including a Thesis Binders University Of London phase 2 study of anti-Clostridium difficile mAbs to prevent recurrent diarrheal disease. He also led the landmark first combination study of ipilimumab and nivolumab prior to moving to Regeneron. Krzysztof Masternak received his Ph. In this position, she successfully developed and executed the late preclinical and early clinical strategy for a novel platform technology, managed meetings with European and US regulatory authorities and led manufacturing and CMC strategy for a new biological entity targeting cancer.
InMatthias Peipp received his Ph. In mid Matthias was awarded an endowed professorship for experimental antibody-based cancer immunotherapy from the German Cancer Aid. His current work is focused on the generation and functional characterization of engineered therapeutic antibodies and antibody derivatives to modulate immune effector cell recruitment.
In addition, she holds responsibility for the Alliance Management team. She received a Ph. Before article source industry she held a research position at the University of Regensburg.
With his team, he develops new methodologies enabling the generation and screening of several thousand binders per week which are used in numerous international collaborations.
Prior to his current position, Jonas performed his PhD studies with Prof. Janine Schuurman has been working in the field of Antibody Biology for about 20 years. During her PhD at Sanquin Research. Sun is currently working in the department of Translation Oncology at Genentech, leading the research efforts in developing T-cell dependent bispecific antibodies as potential therapeutics for B cell malignancies.
Prior to Genentech, she obtained her Ph. He is responsible for providing scientific support, programming custom applications, instructing at workshops, presenting at conferences, and guiding CCG's 3D biologics modeling applications development.
Before joining CCG, Nels majored in biomedical computing at Queen's University in Canada and went on to complete his graduate studies at the University of British Columbia focusing on bioinformatics and computational chemistry.
Since joining Genedata inDr. Wendt has been designing and developing laboratory workflow, data management and data click here solutions for pharma and biotech companies to support their drug discovery and development programs.
She led the design of a novel, integrated biologics registration and workflow Thesis Binders University Of London system for antibody and protein screening, engineering, and production. This culminated in the Genedata Biologics platform currently used at many major biopharma laboratories today. Previously, she also worked on solutions for target validation, biomarker discovery, and drug safety.
She earned her Ph.
He leads a research group within Cancer Sciences studying antibody drugs and their mechanisms of action. Their work utilises a portfolio of complimentary models incorporating in vitro 3D modelling, appropriate in vivo model systems and primary clinical material.
Chu joined Xencor in and is currently Associate Director of the Cell Biology Group responsible for discovery, in vitro, and ex vivo development for all Xencor therapeutic candidates.
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He obtained his Ph. Moreover, he was recently highlighted by both Scientific American and Forbes Magazine to be a future leader in the field of Chemistry. He has research interests in the development and application of novel methodologies in Chemical Biology, resulting in over 30 publications and patents http: In addition, he has been highlighted as a future leader in the field of Chemical Biology by Chemical Communications in a recent special issue Emerging Investigators