learn more here wp-image-289" width="220">Statin medications lower cholesterol levels in your blood. This can reduce the chance of a heart attackstroke, and premature death in people who have an elevated risk of developing heart disease or who already have it.
Statins work by blocking a liver enzyme needed to make cholesterol. The body needs some cholesterol to maintain good health. High blood levels of LDL cholesterol and low levels of HDL cholesterol are associated with an increased risk of arterial blockage throughout the body, which could eventually lead to Literature Review Of Atorvastatin attack, stroke, and peripheral artery disease in the legs.
Statins may also moderately reduce triglyceride levels, decrease inflammation in arteries, and help raise HDL levels.
Some statins are backed by stronger evidence than others that they lower cholesterol or reduce the risk of a heart attack or premature death from heart disease or a stroke.
Our recommendations about who should consider a statin drug to lower their cardiovascular risks are based in part on new guidelines from the American College of Cardiology and the American Heart Association. But the new guidelines consider your overall risk of a heart attack or stroke in the next 10 years more important than LDL cholesterol levels alone. The guidelines determine your risk based on additional factors, including your age, blood pressure level, whether you smoke, are overweight, or have diabetes or other medical problems.
Diet and lifestyle changessuch as quitting smoking, losing weight if you need to, and exercise, can help lower your risk of heart attack and stroke.
Regardless Literature Review Of Atorvastatin whether you take a statin or not, you should still follow them. Most people who take a statin must continue to do so for years—perhaps for the rest of their life—so the cost can be an important factor to consider. See the price chart below for the generic statins that are likely to be available through these programs.
Our medical advisers say that if you fall into this category, you should consider a statin, but for some people, especially those with a year risk less than 10 percent, diet and lifestyle changes could be the first step—those changes could lower your risk enough that you are no longer considered a Literature Review Of Atorvastatin for a statin. Taking the evidence for effectiveness, safety, and cost into account, we have chosen the following statins as Consumer Reports Best Buy Drugs.
All of our Best Buys —atorvastatin, lovastatin, pravastatin, and simvastatin—have more info shown to reduce the Essay On George Washington Biography of heart attack and deaths from heart attacks, and are available as inexpensive generics. Higher doses and high-intensity statins pose a greater risk of rare, but serious side effects, such as muscle breakdown that can lead to permanent kidney damage, coma, and possibly death.
But some people—such as those who have very high LDL, have suffered a heart attack, or have diabetes—may require a high-intensity statin. No matter which statin or dose you take, if you experience muscle aches and pains when taking a statin, contact your doctor immediately.
To save money, ask your doctor about splitting your statin pills. This can cut your costs substantially and is a widely accepted practice. Cholesterol-lowering statins are used to help prevent heart disease, which can lead to heart attacks, heart failure, and death.
Heart disease is the leading cause of death in the U. Literature Review Of Atorvastatin high LDL cholesterol level increases your risk of heart disease, but it does not necessarily mean you should start on a statin, because LDL is just one risk factor out of several that determine your overall risk. Other factors that raise your risk of heart disease include older age, diabeteshaving a family history of heart diseasehigh blood pressurelack of exercisewhether you are obeseand whether you smoke.
Your doctor should ask you about those risk factors and take them into consideration before deciding Literature Review Of Atorvastatin a statin is appropriate for you.
The use of statins has increased sharply in recent years, and they are now among the most widely prescribed medicines in the U. Twenty-two percent of Americans 45 years and older take a statin drug, according to the most recent data from the National Health and Nutrition Examination Survey. One statin, Crestor rosuvastatinwas the third-top-selling drug in the U. This analysis compares statin drugs with each other and will help you talk with your doctor about your choices and heart-disease risk.
In addition, combination products containing read more statin and another lipid-lowering drug are available in the U.
These drugs are listed below. The increase in statin prescriptions has prompted controversy over the appropriate use of the drugs. If your risk is at or above 7.
Those changes could lower your risk enough that you are no longer considered a candidate for a statin. Even after years of attention to this issue, many people Literature Review Of Atorvastatin confused about what constitutes a cholesterol-lowering and heart-healthy diet. For example, many still believe that simply cutting cholesterol-laden eggs out of their diet will do the trick. Following a Mediterranean diet supplemented with olive oil or nuts is the only diet that has been shown in a clinical trial to reduce the risk of heart attacks and strokes.
To learn more about a healthy diet, go to Consumer Reports heart health site. Our recommendations about who should consider a statin drug are based in part on guidelines from the American College of Cardiology and the American Heart Association released in Those guidelines recommend that your doctor prescribe either a moderate- or high-intensity statin if you Literature Review Of Atorvastatin into one of four groups below.
A moderate-intensity statin is expected to reduce LDL cholesterol by 30 percent to 50 percent, while a high-intensity statin would reduce LDL by 50 percent or more. Previous strategies focused on reducing elevated LDL cholesterol levels to very low levels.
But the new guidelines look at your overall risk of a heart attack or stroke in the next 10 years as more important than LDL cholesterol levels alone.
To calculate your risk of suffering a heart attack or more info over the next 10 years, the new guidelines use a calculator, found here: It uses your age, blood pressure, gender, levels of total and HDL cholesterol, race, and whether you smoke or have diabetes to generate a risk score. This calculator generated controversy when it was released in November Some experts argued it might overestimate Literature Review Of Atorvastatin person's risk, and could put people on a statin who don't actually need one.
It's good to know that this and other calculators are intended to help estimate you overall cardiovascular risk. The results are simply a guide for you and your doctor to use in deciding if you should take a statin. The table below lists the four groups of people the new guidelines recommend should receive a statin. Literature Review Of Atorvastatin a moderate- to high-intensity Literature Review Of Atorvastatin. Some say it should be as high as 20 percent while others think it should be 10 percent.
As noted above, the new guidelines recommend that people in this group consider a statin. That step would include adopting a healthy diet that is low in saturated fats, trans fats, and cholesterol, and making lifestyle changes such as exercising and losing weight if you need to or quitting smoking if you are a smoker. In making your decision, our medical advisers recommend that you consider the risk of side effects and also look at how taking a statin will reduce learn more here risk.
You might find that a statin will not make much difference in your year risk. All the statins have been found to reduce levels of LDL cholesterol. And all but two have been found to lower the risk of heart attack and death from heart disease in people with moderate to high risk of heart disease and those who have heart disease or have had a heart attack.
But statins differ in their ability to reduce LDL cholesterol.
And the evidence is stronger for some statins when it comes to reducing your risk of heart attack or death from heart disease or stroke. Statins also vary widely in cost. As mentioned, five are now available as generics, and you can save a significant amount of money if you and your doctor choose one of them. This may also help you stay on the drug.
Of course, price is not the Literature Review Of Atorvastatin important factor in choosing a statin. As we previously discussed, you and your doctor will want to consider:.
People who have already suffered a heart attack are at very high risk of another possibly fatal heart attack and generally benefit from lowering their LDL cholesterol visit web page much as possible. People who have had a heart attack will probably be prescribed several different kinds of drugs, including a statin, and lifestyle changes will be strongly urged.
In studies involving heart patients, atorvastatin has been shown to reduce the risk of second heart attacks and deaths, strokes, and major heart problems.
In addition, atorvastatin may be a better option for people who have had a heart attack and need greater LDL reduction. Several statins—atorvastatin, pravastatin, simvastatin, and rosuvastatin Crestor —have been proven to prevent strokes. An analysis by the Cochrane Collaboration found that the available evidence indicates overall that statins reduce the risk of fatal and nonfatal strokes by 22 percent.
Fluvastatin and pitavastatin have not been clearly proven to reduce heart attacks, strokes, or deaths.
Have high cholesterol? Find out about Statin Drugs used to treat it from Consumer Reports. Lipitor (Atorvastatin) is prescribed to lower cholesterol and triglycerides in the blood. Original Article. High-Dose Atorvastatin after Stroke or Transient Ischemic Attack. The Stroke Prevention by Aggressive Reduction in Cholesterol Levels (SPARCL. Lovastatin, a compound isolated from Aspergillus terreus, was the first statin to be marketed. Results. The mean LDL cholesterol levels were 77 mg per deciliter ( mmol per liter) during treatment with 80 mg of atorvastatin and mg per deciliter ( mmol.
Crestor has been shown to reduce heart attacks and deaths, but there Literature Review Of Atorvastatin no reason to take it instead of generic atorvastatin, which is about half the price, depending on dose.
There is one other important issue you should know about as you and your doctor choose a statin. For people who are at high risk of heart attack—for example, if you just click for source diabetes, are a smoker and have elevated LDL levels—studies indicate that the lower your LDL, the lower the risk of heart attack and stroke. Since higher doses and high intensity statins reduce LDL cholesterol more, the hypothesis has been that they are better and should be used more liberally.
But higher doses and high-intensity statins come with more side effects. Higher doses of all statins have been linked to muscle aches, soreness, tenderness, or weakness. Studies indicate that between one in 20 to one in 10 people who take a statin—regardless of dose—experience these symptoms, and up to 10 percent in some studies have not been able to tolerate an 80 mg dose.
Higher doses have also been linked to an increased risk of a life-threatening form of muscle breakdown called rhabdomyolysis. This can lead to permanent kidney damage, coma, and death.
So even if you fall into a category that should receive a high-intensity statin, we advise caution and careful monitoring for the occurrence of side effects. If you are already taking a low-intensity statin, such as simvastatin 10 mg, pravastatin 10 mg or 20 mg, lovastatin 20 mg, fluvastatin 20 mg or 40 mg, or pitavastatin 1 mg, the new guidelines do not mean that you should necessarily switch to a moderate- or high-intensity statin.
This could be a good time to review your risk factors with your doctor to figure out your current risk level and determine whether or not it makes sense to change to a different statin.
Statins reduce the risk of a first heart attack and repeat heart attacks, as well as the risk of death from heart attacks and other forms of heart Literature Review Of Atorvastatin. But some have been studied more extensively than others in terms of both their effectiveness and their safety. And ongoing research continues to define how the statins work and how they differ.
Although all statins reduce LDL cholesterol levels, they have article source been evaluated by three other criteria to determine if the drug:. Four statins—atorvastatin Lipitor and genericlovastatin Altoprev, Mevacor, and genericpravastatin Pravachol and genericand simvastatin Zocor and generic —have been proven to reduce the risk of heart attack over three to five years of use.
And rosuvastatin Crestor has been shown to reduce the risk of heart attack over 1. But you should know that the longest studies have only looked at several years of use and no studies have looked at the impact of taking these drugs for 20 to 30 years or longer, the length of time that many people will wind up taking the medicines. Fluvastatin Lescol and Lescol XL and pitavastatin Livalo have not been shown to prevent heart attacks and strokes.
In one three-year study that looked at preventing a first heart attack, 5 percent of people who took a placebo had a heart attack compared to 3 percent of those who took a statin. Of those taking statins, 6 percent had a heart attack, coronary event, or stroke versus 8 percent of those taking a placebo. Four statins—atorvastatin Lipitor and generic ; lovastatin Altoprev, Mevacor, and generic ; pravastatin Pravachol and genericand simvastatin Zocor and generic —have been found to reduce deaths from heart attacks among patients with a history of heart disease or risk factors for heart disease, such as diabetes and high blood pressure.
In addition, two of the statins—pravastatin and simvastatin—have been found to reduce the overall risk of dying among people considered to be at low risk of heart disease or heart attack. A major study of lovastatin has strongly suggested a similar benefit.